LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells

Melanoma cells steer out of tumours using self-generated lysophosphatidic acid (LPA) gradients. The cells break down LPA, which is present at high levels around the tumours, creating a dynamic gradient that is low in the tumour and high outside. They then migrate up this gradient, creating a complex...

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Bibliografske podrobnosti
izdano v:J Cell Sci
Main Authors: Susanto, Olivia, Koh, Yvette W. H., Morrice, Nick, Tumanov, Sergey, Thomason, Peter A., Nielson, Matthew, Tweedy, Luke, Muinonen-Martin, Andrew J., Kamphorst, Jurre J., Mackay, Gillian M., Insall, Robert H.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665449/
https://ncbi.nlm.nih.gov/pubmed/28871044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.207514
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