N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis

Pancreatic ductal adenocarcinoma is one of the most invasive and metastatic cancers and has a dismal 5-year survival rate. We show that N-WASP drives pancreatic cancer metastasis, with roles in both chemotaxis and matrix remodeling. lysophosphatidic acid, a signaling lipid abundant in blood and asci...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Juin, Amelie, Spence, Heather J., Martin, Kirsty J., McGhee, Ewan, Neilson, Matthew, Cutiongco, Marie F.A., Gadegaard, Nikolaj, Mackay, Gillian, Fort, Loic, Lilla, Sergio, Kalna, Gabriela, Thomason, Peter, Koh, Yvette W.H., Norman, Jim C., Insall, Robert H., Machesky, Laura M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863394/
https://ncbi.nlm.nih.gov/pubmed/31668663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.09.018
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados