Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis

BACKGROUND: A subset of familial forms of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene coding Cu/Zn-superoxide dismutase (SOD1). Mutant SOD1 proteins are susceptible to misfolding and abnormally accumulated in spinal cord, which is most severely affected in ALS. It, howeve...

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Pubblicato in:Mol Neurodegener
Autori principali: Tokuda, Eiichi, Takei, Yo-ichi, Ohara, Shinji, Fujiwara, Noriko, Hozumi, Isao, Furukawa, Yoshiaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862823/
https://ncbi.nlm.nih.gov/pubmed/31744522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0341-5
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