Screening of Drugs Inhibiting In vitro Oligomerization of Cu/Zn-Superoxide Dismutase with a Mutation Causing Amyotrophic Lateral Sclerosis

Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) gene have been shown to cause a familial form of amyotrophic lateral sclerosis (SOD1-ALS). A major pathological hallmark of this disease is abnormal accumulation of mutant SOD1 oligomers in the affected spinal motor neurons. While no effective...

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Опубликовано в: :Front Mol Biosci
Главные авторы: Anzai, Itsuki, Toichi, Keisuke, Tokuda, Eiichi, Mukaiyama, Atsushi, Akiyama, Shuji, Furukawa, Yoshiaki
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2016
Предметы:
Molecular Biosciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977284/
https://ncbi.nlm.nih.gov/pubmed/27556028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00040
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