A misfolded dimer of Cu/Zn‐superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis

Misfolding of mutant Cu/Zn‐superoxide dismutase (SOD1) is a pathological hallmark in a familial form of amyotrophic lateral sclerosis. Pathogenic mutations have been proposed to monomerize SOD1 normally adopting a homodimeric configuration and then trigger abnormal oligomerization of SOD1 proteins....

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Publicat a:Protein Sci
Autors principals: Anzai, Itsuki, Tokuda, Eiichi, Mukaiyama, Atsushi, Akiyama, Shuji, Endo, Fumito, Yamanaka, Koji, Misawa, Hidemi, Furukawa, Yoshiaki
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5326558/
https://ncbi.nlm.nih.gov/pubmed/27977888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3094
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