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Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential

Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner caspases, most notably caspase-3, that proteolyze a variety of proteins, inducing cell death. Paradoxically, overexpression of procaspase-3 (PC-3)...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Boudreau, Matthew W., Peh, Jessie, Hergenrother, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858495/
https://ncbi.nlm.nih.gov/pubmed/31260254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00338
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