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Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule Mediated MEK Degradation
The discovery of mutant or fusion kinases that drive oncogenesis, and the subsequent approval of specific inhibitors for these enzymes, has been instrumental in the management of some cancers. However, acquired resistance remains a significant problem in the clinic, limiting the long-term effectiven...
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| Udgivet i: | Cell Chem Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6097934/ https://ncbi.nlm.nih.gov/pubmed/29909991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.05.008 |
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