Small Molecule-facilitated Degradation of ANO1 Protein: A NEW TARGETING APPROACH FOR ANTICANCER THERAPEUTICS

ANO1, a calcium-activated chloride channel, is highly expressed and amplified in human cancers and is a critical survival factor in these cancers. The ANO1 inhibitor CaCC(inh)-A01 decreases proliferation of ANO1-amplified cell lines; however, the mechanism of action remains elusive. We explored the...

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Hlavní autoři: Bill, Anke, Hall, Michelle Lynn, Borawski, Jason, Hodgson, Catherine, Jenkins, Jeremy, Piechon, Philippe, Popa, Oana, Rothwell, Christopher, Tranter, Pamela, Tria, Scott, Wagner, Trixie, Whitehead, Lewis, Gaither, L. Alex
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036244/
https://ncbi.nlm.nih.gov/pubmed/24599954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.549188
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