Variomics Screen Identifies the Re-entrant Loop of the Calcium-activated Chloride Channel ANO1 That Facilitates Channel Activation

The calcium-activated chloride channel ANO1 regulates multiple physiological processes. However, little is known about the mechanism of channel gating and regulation of ANO1 activity. Using a high-throughput, random mutagenesis-based variomics screen, we generated and functionally characterized ∼600...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bill, Anke, Popa, M. Oana, van Diepen, Michiel T., Gutierrez, Abraham, Lilley, Sarah, Velkova, Maria, Acheson, Kathryn, Choudhury, Hedaythul, Renaud, Nicole A., Auld, Douglas S., Gosling, Martin, Groot-Kormelink, Paul J., Gaither, L. Alex
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294516/
https://ncbi.nlm.nih.gov/pubmed/25425649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.618140
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