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Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule Mediated MEK Degradation

The discovery of mutant or fusion kinases that drive oncogenesis, and the subsequent approval of specific inhibitors for these enzymes, has been instrumental in the management of some cancers. However, acquired resistance remains a significant problem in the clinic, limiting the long-term effectiven...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Peh, Jessie, Boudreau, Matthew W., Smith, Hannah M., Hergenrother, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097934/
https://ncbi.nlm.nih.gov/pubmed/29909991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.05.008
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