MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance

Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to promote the localization of other factors, including 53BP1, to DSB sites. Here, by usi...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Salguero, Israel, Belotserkovskaya, Rimma, Coates, Julia, Sczaniecka-Clift, Matylda, Demir, Mukerrem, Jhujh, Satpal, Wilson, Marcus D., Jackson, Stephen P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858307/
https://ncbi.nlm.nih.gov/pubmed/31729360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12929-5
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