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Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity

DNA strand breaks trigger marked phosphorylation of histone H2AX (i.e. γ-H2AX). While DNA double-strand breaks (DSBs) provide a strong stimulus for this event, the accompanying structural alterations in chromatin may represent the actual signal that elicits γ-H2AX. Our data show that changes in chro...

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Hlavní autoři: Baure, Jennifer, Izadi, Atefeh, Suarez, Vannina, Giedzinski, Erich, Cleaver, James E., Fike, John R., Limoli, Charles L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648872/
https://ncbi.nlm.nih.gov/pubmed/19064695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gen064
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