Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair

Ubiquitylation is crucial for proper cellular responses to DNA double-strand breaks (DSBs). If unrepaired, these highly cytotoxic lesions cause genome instability, tumourigenesis, neurodegeneration or premature ageing. Here, we conduct a comprehensive, multilayered screen to systematically profile a...

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Udgivet i:Nat Cell Biol
Main Authors: Schmidt, Christine K, Galanty, Yaron, Sczaniecka-Clift, Matylda, Coates, Julia, Jhujh, Satpal, Demir, Mukerrem, Cornwell, Matthew, Beli, Petra, Jackson, Stephen P
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894550/
https://ncbi.nlm.nih.gov/pubmed/26502057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3260
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