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Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair
Ubiquitylation is crucial for proper cellular responses to DNA double-strand breaks (DSBs). If unrepaired, these highly cytotoxic lesions cause genome instability, tumourigenesis, neurodegeneration or premature ageing. Here, we conduct a comprehensive, multilayered screen to systematically profile a...
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| Publicado no: | Nat Cell Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4894550/ https://ncbi.nlm.nih.gov/pubmed/26502057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3260 |
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