Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites

The activities of many DNA-repair proteins are controlled through reversible covalent modification by ubiquitin and ubiquitin-like molecules. Nonhomologous end-joining (NHEJ) is the predominant DNA double-strand break (DSB) repair pathway in mammalian cells and is initiated by DSB ends being recogni...

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Publié dans:Cell Rep
Auteurs principaux: Brown, Jessica S., Lukashchuk, Natalia, Sczaniecka-Clift, Matylda, Britton, Sébastien, le Sage, Carlos, Calsou, Patrick, Beli, Petra, Galanty, Yaron, Jackson, Stephen P.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431666/
https://ncbi.nlm.nih.gov/pubmed/25921528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.03.058
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