CtIP tetramer assembly is required for DNA-end resection and repair

Mammalian CtIP protein plays major roles in DNA double-strand break (DSB) repair. While it is well-established that CtIP promotes DNA-end resection in preparation for homology-dependent DSB repair, the molecular basis for this function remains unknown. Here we show by biophysical and X-ray crystallo...

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Publicat a:Nat Struct Mol Biol
Autors principals: Davies, Owen R., Forment, Josep V., Sun, Meidai, Belotserkovskaya, Rimma, Coates, Julia, Galanty, Yaron, Demir, Mukerrem, Morton, Christopher R., Rzechorzek, Neil J., Jackson, Stephen P., Pellegrini, Luca
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564947/
https://ncbi.nlm.nih.gov/pubmed/25558984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2937
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