Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal

Purpose: Retinal organoids generated from human pluripotent stem cells exhibit considerable variability during differentiation. Our goals are to assess developmental maturity of the neural retina in vitro and design improved protocols based on objective criteria. Methods: We performed transcriptome...

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Publicat a:Mol Vis
Autors principals: Kaya, Koray D., Chen, Holly Y., Brooks, Matthew J., Kelley, Ryan A., Shimada, Hiroko, Nagashima, Kunio, de Val, Natalia, Drinnan, Charles T., Gieser, Linn, Kruczek, Kamil, Erceg, Slaven, Li, Tiansen, Lukovic, Dunja, Adlakha, Yogita K., Welby, Emily, Swaroop, Anand
Format: Artigo
Idioma:Inglês
Publicat: Molecular Vision 2019
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857775/
https://ncbi.nlm.nih.gov/pubmed/31814692
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