Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo

Stem cell-derived retinal organoids recapitulate many landmarks of in vivo differentiation but lack functional maturation of distinct cell types, especially photoreceptors. Using comprehensive temporal transcriptome analyses, we show that transcriptome shift from postnatal day 6 (P6) to P10, associa...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Brooks, Matthew J., Chen, Holly Y., Kelley, Ryan A., Mondal, Anupam K., Nagashima, Kunio, De Val, Natalia, Li, Tiansen, Chaitankar, Vijender, Swaroop, Anand
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895716/
https://ncbi.nlm.nih.gov/pubmed/31631019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.09.009
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