Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function

Allosteric changes imposed by post-translational modifications regulate and differentiate the functions of proteins with intrinsic disorder regions. HDM2 is a hub protein with a large interactome and with different cellular functions. It is best known for its regulation of the p53 tumour suppressor....

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Bibliographische Detailangaben
Veröffentlicht in:Biochem J
Hauptverfasser: Uhrik, Lukas, Wang, Lixiao, Haronikova, Lucia, Medina-Medina, Ixaura, Rebolloso-Gomez, Yolanda, Chen, Sa, Vojtesek, Borivoj, Fahraeus, Robin, Hernychova, Lenka, Olivares-Illana, Vanesa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2019
Schlagworte:
Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857739/
https://ncbi.nlm.nih.gov/pubmed/31652301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190687
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