Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia. A Pilot Randomized Controlled Clinical Trial

Rationale: Population studies suggest improved sepsis outcomes with statins, but the results of randomized controlled trials in patients with sepsis and organ dysfunction in critical care settings have broadly been negative. In vitro data suggest that statins modulate age-related neutrophil function...

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Pubblicato in:Am J Respir Crit Care Med
Autori principali: Sapey, Elizabeth, Patel, Jaimin M., Greenwood, Hannah, Walton, Georgia M., Grudzinska, Frances, Parekh, Dhruv, Mahida, Rahul Y., Dancer, Rachel C. A., Lugg, Sebastian T., Howells, Philip A., Hazeldine, Jon, Newby, Paul, Scott, Aaron, Nightingale, Peter, Hill, Adam T., Thickett, David R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2019
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857486/
https://ncbi.nlm.nih.gov/pubmed/31206313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201812-2328OC
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