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Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome
Rett Syndrome (RTT) is an X-linked neurodevelopmental disorder associated with respiratory abnormalities and, in up to ~40% of patients, with prolongation of the cardiac QT(c) interval. QT(c) prolongation calls for cautious use of drugs with a propensity to inhibit hERG channels. The STARS trial has...
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| Udgivet i: | J Mol Cell Cardiol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Academic Press
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6856717/ https://ncbi.nlm.nih.gov/pubmed/31362019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.07.012 |
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