DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency

The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its target loci. Here, we demonstrate that 3D genome organization...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: McLaughlin, Katy, Flyamer, Ilya M., Thomson, John P., Mjoseng, Heidi K., Shukla, Ruchi, Williamson, Iain, Grimes, Graeme R., Illingworth, Robert S., Adams, Ian R., Pennings, Sari, Meehan, Richard R., Bickmore, Wendy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856714/
https://ncbi.nlm.nih.gov/pubmed/31722211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.031
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