Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells

BACKGROUND: Thousands of mammalian promoters are defined by co-enrichment of the histone tail modifications H3K27me3 (repressive) and H3K4me3 (activating) and are thus termed bivalent. It was previously observed that bivalent genes in human ES cells (hESC) are frequent targets for hypermethylation i...

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Udgivet i:BMC Biol
Main Authors: Dunican, Donnchadh S., Mjoseng, Heidi K., Duthie, Leanne, Flyamer, Ilya M., Bickmore, Wendy A., Meehan, Richard R.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057567/
https://ncbi.nlm.nih.gov/pubmed/32131813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-0752-3
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