DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency

The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its target loci. Here, we demonstrate that 3D genome organization...

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Vydáno v:Cell Rep
Hlavní autoři: McLaughlin, Katy, Flyamer, Ilya M., Thomson, John P., Mjoseng, Heidi K., Shukla, Ruchi, Williamson, Iain, Grimes, Graeme R., Illingworth, Robert S., Adams, Ian R., Pennings, Sari, Meehan, Richard R., Bickmore, Wendy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856714/
https://ncbi.nlm.nih.gov/pubmed/31722211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.031
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