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Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress

Clonal microbial populations are inherently heterogeneous, and this diversification is often considered as an adaptation strategy. In clinical infections, phenotypic diversity is found to be associated with drug tolerance, which in turn could evolve into genetic resistance. Mycobacterium tuberculosi...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Manina, Giulia, Griego, Anna, Singh, Lalit Kumar, McKinney, John D, Dhar, Neeraj
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856624/
https://ncbi.nlm.nih.gov/pubmed/31583725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019101876
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