Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells

Mycobacterium tuberculosis (Mtb) defends itself against host immunity and chemotherapy at several levels, including the repair or degradation of irreversibly oxidized proteins (IOPs). To investigate how Mtb deals with IOPs that can neither be repaired nor degraded, we used new chemical and biochemic...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Vaubourgeix, Julien, Lin, Gang, Dhar, Neeraj, Chenouard, Nicolas, Jiang, Xiuju, Botella, Helene, Lupoli, Tania, Mariani, Olivia, Yang, Guangli, Ouerfelli, Ouathek, Unser, Michael, Schnappinger, Dirk, McKinney, John, Nathan, Carl
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707119/
https://ncbi.nlm.nih.gov/pubmed/25620549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.12.008
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