Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model

Acute lymphoblastic leukemia (ALL) develops in the bone marrow in the vicinity of stromal cells known to promote tumor development and treatment resistance. We previously showed that the cyclooxygenase (COX) inhibitor indomethacin prevents the ability of stromal cells to diminish p53-mediated killin...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Richartz, Nina, Duthil, Eva, Ford, Anthony, Naderi, Elin Hallan, Bhagwat, Sampada, Gilljam, Karin M., Burman, Marta Maria, Ruud, Ellen, Blomhoff, Heidi Kiil, Skah, Seham
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855122/
https://ncbi.nlm.nih.gov/pubmed/31698450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000473
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