Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA

BACKGROUND: APOBEC1 (A1) enzymes are cytidine deaminases involved in RNA editing. In addition to this activity, a few A1 enzymes have been shown to be active on single stranded DNA. As two human ssDNA cytidine deaminases APOBEC3A (A3A), APOBEC3B (A3B) and related enzymes across the spectrum of place...

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Bibliographic Details
Published in:BMC Genomics
Main Authors: Caval, Vincent, Jiao, Wenjuan, Berry, Noémie, Khalfi, Pierre, Pitré, Emmanuelle, Thiers, Valérie, Vartanian, Jean-Pierre, Wain-Hobson, Simon, Suspène, Rodolphe
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854741/
https://ncbi.nlm.nih.gov/pubmed/31726973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-019-6216-x
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