CYP2B6 Genotype‐Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers

We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N‐acetyltransferase 2 (NAT2), using caffeine as a probe. A single 150 mg oral dose of caffeine was administered to healthy volunteers (n = 58) on two separate occasions; with a s...

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Detalles Bibliográficos
Publicado en:Clin Transl Sci
Main Authors: Metzger, Ingrid F., Dave, Nimita, Kreutz, Yvonne, Lu, Jessica B.L., Galinsky, Raymond E., Desta, Zeruesenay
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853154/
https://ncbi.nlm.nih.gov/pubmed/31339646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12671
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