Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers

Cytochrome P450 2B6 (CYP2B6) metabolizes clinically important drugs and other compounds. Its expression and activity vary widely among individuals, but quantitative estimation is hampered by the lack of safe and selective in vivo probes of CYP2B6 activity. Efavirenz, a nonnucleoside HIV-1 reverse tr...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Desta, Zeruesenay, Metzger, Ingrid F., Thong, Nancy, Lu, Jessica B. L., Callaghan, John T., Skaar, Todd C., Flockhart, David A., Galinsky, Raymond E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075090/
https://ncbi.nlm.nih.gov/pubmed/27600044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01000-16
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