Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers

Cytochrome P450 2B6 (CYP2B6) metabolizes clinically important drugs and other compounds. Its expression and activity vary widely among individuals, but quantitative estimation is hampered by the lack of safe and selective in vivo probes of CYP2B6 activity. Efavirenz, a nonnucleoside HIV-1 reverse tr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Desta, Zeruesenay, Metzger, Ingrid F., Thong, Nancy, Lu, Jessica B. L., Callaghan, John T., Skaar, Todd C., Flockhart, David A., Galinsky, Raymond E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2016
Pynciau:
Pharmacology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075090/
https://ncbi.nlm.nih.gov/pubmed/27600044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01000-16
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