Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers

The effect of rifampin on the in vivo metabolism of the antiretroviral drug efavirenz was evaluated in healthy volunteers. In a cross-over placebo control trial, healthy subjects (n = 20) were administered a single 600 mg oral dose of efavirenz after pretreatment with placebo or rifampin (600 mg/day...

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Publicado en:Drug Metab Pharmacokinet
Main Authors: Cho, Doo-Yeoun, Shen, Joan H.Q., Lemler, Suzanne M., Skaar, Todd C, Li, Lang, Blievernicht, Julia, Zanger, Ulrich M., Kim, Kwon-Bok, Shin, Jae-Gook, Flockhart, David A., Desta, Zeruesenay
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974081/
https://ncbi.nlm.nih.gov/pubmed/27053325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dmpk.2015.07.002
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