Reduced exposure to piperaquine, compared to adults, in young children receiving dihydroartemisinin-piperaquine as malaria chemoprevention

Dihydroartemisinin (DHA)-piperaquine is being evaluated as intermittent preventive therapy for malaria, but dosing has not been optimized for children. We assessed exposure to DHA and piperaquine in Ugandan children at two ages during infancy. Intensive sampling was performed in 32 children at 32 we...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Whalen, Meghan E., Kajubi, Richard, Chamankhah, Nona, Huang, Liusheng, Orukan, Francis, Wallender, Erika, Kamya, Moses R, Dorsey, Grant, Jagannathan, Prasanna, Rosenthal, Philip J., Mwebaza, Norah, Aweeka, Francesca T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851416/
https://ncbi.nlm.nih.gov/pubmed/31173649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1534
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