Reduced exposure to piperaquine, compared to adults, in young children receiving dihydroartemisinin-piperaquine as malaria chemoprevention

Dihydroartemisinin (DHA)-piperaquine is being evaluated as intermittent preventive therapy for malaria, but dosing has not been optimized for children. We assessed exposure to DHA and piperaquine in Ugandan children at two ages during infancy. Intensive sampling was performed in 32 children at 32 we...

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發表在:Clin Pharmacol Ther
Main Authors: Whalen, Meghan E., Kajubi, Richard, Chamankhah, Nona, Huang, Liusheng, Orukan, Francis, Wallender, Erika, Kamya, Moses R, Dorsey, Grant, Jagannathan, Prasanna, Rosenthal, Philip J., Mwebaza, Norah, Aweeka, Francesca T.
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851416/
https://ncbi.nlm.nih.gov/pubmed/31173649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1534
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