Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children

BACKGROUND: Anti-malarial chemoprevention with dihydroartemisinin-piperaquine (DHA/PQ) is a promising tool for malaria control, but its efficacy in children may be limited by inadequate drug exposure. METHODS: Children were enrolled in a non directly-observed trial of DHA/PQ chemoprevention in a hig...

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Vydáno v:Malar J
Hlavní autoři: Sundell, Kerstin, Jagannathan, Prasanna, Huang, Liusheng, Bigira, Victor, Kapisi, James, Kakuru, Mary M., Savic, Rada, Kamya, Moses R., Dorsey, Grant, Aweeka, Francesca
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582734/
https://ncbi.nlm.nih.gov/pubmed/26403465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-015-0908-8
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