In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity‐based protein profiling

Glucocerebrosidase (GBA) is a lysosomal β‐glucosidase‐degrading glucosylceramide. Its deficiency causes Gaucher disease (GD), a common lysosomal storage disorder. Carrying a genetic abnormality in GBA constitutes at present the largest genetic risk factor for Parkinson's disease (PD). Condurito...

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Pubblicato in:FEBS J
Autori principali: Kuo, Chi‐Lin, Kallemeijn, Wouter W., Lelieveld, Lindsey T., Mirzaian, Mina, Zoutendijk, Iris, Vardi, Ayelet, Futerman, Anthony H., Meijer, Annemarie H., Spaink, Herman P., Overkleeft, Herman S., Aerts, Johannes M.F.G., Artola, Marta
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850446/
https://ncbi.nlm.nih.gov/pubmed/30600575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14744
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