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Aspartate residues far from the active site drive O-GlcNAc transferase substrate selection
O-GlcNAc is an abundant post-translational modification found on nuclear and cytoplasmic proteins in all metazoans. This modification regulates a wide variety of cellular processes, and elevated O-GlcNAc levels have been implicated in cancer progression. A single essential enzyme, O-GlcNAc transfera...
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| Veröffentlicht in: | J Am Chem Soc |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6849375/ https://ncbi.nlm.nih.gov/pubmed/31373491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b06061 |
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