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Engineering a proximity-directed O-GlcNAc transferase for selective protein O-GlcNAcylation in cells

O-Linked N-acetylglucosamine (O-GlcNAc) is a monosaccharide that plays an essential role in cellular signaling throughout the nucleocytoplasmic proteome of eukaryotic cells. Strategies to selectively increase O-GlcNAc levels on a target protein in cells would accelerate studies of this essential mod...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Chem Biol
Prif Awduron: Ramirez, Daniel H., Aonbangkhen, Chanat, Wu, Hung-Yi, Naftaly, Jeffrey A., Tang, Stephanie, O’Meara, Timothy R., Woo, Christina M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296736/
https://ncbi.nlm.nih.gov/pubmed/32119511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00074
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