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O-GlcNAcylation and O-GlcNAc Cycling Regulate Gene Transcription: Emerging Roles in Cancer

SIMPLE SUMMARY: O-linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (PTM) linking nutrient flux through the hexosamine biosynthetic pathway (HBP) to gene transcription. Mounting experimental and clinical data implicates aberrant O-GlcNAcylation in the development and progr...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Parker, Matthew P., Peterson, Kenneth R., Slawson, Chad
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8037238/
https://ncbi.nlm.nih.gov/pubmed/33916244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13071666
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