mTOR/MYC Axis Regulates O-GlcNAc Transferase (OGT) Expression and O-GlcNAcylation in Breast Cancer

Cancers exhibit altered metabolism characterized by increased glucose and glutamine uptake. The hexosamine biosynthetic pathway (HBP) utilizes glucose and glutamine, and directly contributes to O-linked-β-N-acetylglucosamine (O-GlcNAc) modifications on intracellular proteins. Multiple tumor types co...

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Udgivet i:Mol Cancer Res
Main Authors: Sodi, Valerie L., Khaku, Sakina, Krutilina, Raisa, Schwab, Luciana P., Vocadlo, David J., Seagroves, Tiffany N., Reginato, Mauricio J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433402/
https://ncbi.nlm.nih.gov/pubmed/25636967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0536
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