Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase

O-GlcNAc transferase (OGT), found in the nucleus and cytoplasm of all mammalian cell types, is essential for cell proliferation. Why OGT is required for cell growth is not known. OGT performs two enzymatic reactions in the same active site. In one, it glycosylates thousands of different proteins, an...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Levine, Zebulon G., Potter, Sarah C., Joiner, Cassandra M., Fei, George Q., Nabet, Behnam, Sonnett, Matthew, Zachara, Natasha E., Gray, Nathanael S., Paulo, Joao A., Walker, Suzanne
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848692/
https://ncbi.nlm.nih.gov/pubmed/33419956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016778118
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