Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase

O-GlcNAc transferase (OGT), found in the nucleus and cytoplasm of all mammalian cell types, is essential for cell proliferation. Why OGT is required for cell growth is not known. OGT performs two enzymatic reactions in the same active site. In one, it glycosylates thousands of different proteins, an...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Levine, Zebulon G., Potter, Sarah C., Joiner, Cassandra M., Fei, George Q., Nabet, Behnam, Sonnett, Matthew, Zachara, Natasha E., Gray, Nathanael S., Paulo, Joao A., Walker, Suzanne
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848692/
https://ncbi.nlm.nih.gov/pubmed/33419956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016778118
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