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Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase
O-GlcNAc transferase (OGT), found in the nucleus and cytoplasm of all mammalian cell types, is essential for cell proliferation. Why OGT is required for cell growth is not known. OGT performs two enzymatic reactions in the same active site. In one, it glycosylates thousands of different proteins, an...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7848692/ https://ncbi.nlm.nih.gov/pubmed/33419956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016778118 |
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