CBMT-08. IN VIVO EVALUATION OF PENTOSE PHOSPHATE PATHWAY ACTIVITY IN ORTHOTOPIC GLIOMA USING HYPERPOLARIZED δ-[1-(13)C]GLUCONOLACTONE

The pentose phosphate pathway (PPP) generates NADPH and ribose 5-phosphate, which are involved in the scavenging of reactive oxygen species and the synthesis of nucleotides. As such, the PPP is typically upregulated in cancer cells to address the metabolic needs of rapid cell proliferation. Imaging...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Batsios, Georgios, Viswanath, Pavithra, Cao, Peng, Taglang, Celine, Subramani, Elavarasan, Flavell, Robert, Larson, Peder, Ronen, Sabrina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Cell Biology and Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847728/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.130
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