CBMT-08. IN VIVO EVALUATION OF PENTOSE PHOSPHATE PATHWAY ACTIVITY IN ORTHOTOPIC GLIOMA USING HYPERPOLARIZED δ-[1-(13)C]GLUCONOLACTONE

The pentose phosphate pathway (PPP) generates NADPH and ribose 5-phosphate, which are involved in the scavenging of reactive oxygen species and the synthesis of nucleotides. As such, the PPP is typically upregulated in cancer cells to address the metabolic needs of rapid cell proliferation. Imaging...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Batsios, Georgios, Viswanath, Pavithra, Cao, Peng, Taglang, Celine, Subramani, Elavarasan, Flavell, Robert, Larson, Peder, Ronen, Sabrina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Cell Biology and Metabolism
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847728/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.130
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