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Hyperpolarized δ-[1-(13)C]gluconolactone as a probe of the pentose phosphate pathway

The pentose phosphate pathway (PPP) is thought to be upregulated in trauma (to produce excess NADPH) and in cancer (to provide ribose for nucleotide biosynthesis) but simple methods for detecting changes in flux through this pathway are not available. Magnetic resonance imaging of hyperpolarized (13...

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Publicat a:NMR Biomed
Autors principals: Moreno, Karlos X., Harrison, Crystal E., Merritt, Matthew E., Kovacs, Zoltan, Malloy, Craig R., Sherry, A. Dean
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502806/
https://ncbi.nlm.nih.gov/pubmed/28272754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.3713
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