Hyperpolarized δ-[1-(13)C]gluconolactone as a probe of the pentose phosphate pathway

The pentose phosphate pathway (PPP) is thought to be upregulated in trauma (to produce excess NADPH) and in cancer (to provide ribose for nucleotide biosynthesis) but simple methods for detecting changes in flux through this pathway are not available. Magnetic resonance imaging of hyperpolarized (13...

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Bibliografische gegevens
Gepubliceerd in:NMR Biomed
Hoofdauteurs: Moreno, Karlos X., Harrison, Crystal E., Merritt, Matthew E., Kovacs, Zoltan, Malloy, Craig R., Sherry, A. Dean
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502806/
https://ncbi.nlm.nih.gov/pubmed/28272754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.3713
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