Hyperpolarized δ-[1-(13)C]gluconolactone as a probe of the pentose phosphate pathway

The pentose phosphate pathway (PPP) is thought to be upregulated in trauma (to produce excess NADPH) and in cancer (to provide ribose for nucleotide biosynthesis) but simple methods for detecting changes in flux through this pathway are not available. Magnetic resonance imaging of hyperpolarized (13...

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Bibliographic Details
Published in:NMR Biomed
Main Authors: Moreno, Karlos X., Harrison, Crystal E., Merritt, Matthew E., Kovacs, Zoltan, Malloy, Craig R., Sherry, A. Dean
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502806/
https://ncbi.nlm.nih.gov/pubmed/28272754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.3713
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