Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition

The complex between Trm7 and Trm734 (Trm7–Trm734) from Saccharomyces cerevisiae catalyzes 2′-O-methylation at position 34 in tRNA. We report biochemical and structural studies of the Trm7–Trm734 complex. Purified recombinant Trm7–Trm734 preferentially methylates tRNA(Phe) transcript variants possess...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Hirata, Akira, Okada, Keisuke, Yoshii, Kazuaki, Shiraishi, Hiroyuki, Saijo, Shinya, Yonezawa, Kento, Shimizu, Nobutaka, Hori, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847430/
https://ncbi.nlm.nih.gov/pubmed/31586407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz856
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