DDIS-29. BRAIN-PENETRANT MICROTUBULE-TARGETING AGENT, ST-401, KILLS GLIOBLASTOMA THROUGH A NOVEL MECHANISM

Glioblastomas are particularly sensitive to mitotic disruption when compared with nonmalignant cells and thus microtubule-targeting agents (MTA) represent promising therapeutics to treat patients with glioblastomas; but few such compounds pass the blood brain barrier. We developed a series of modifi...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Horne, Eric, Xu, Cong, Vicente, Juan-Jesus, Cimino, P J, Wagenbach, Michael, Hamel, Ernest, Gussio, Rick, Diaz, Philippe, Uhlenbruck, Benjamin, Deckwerth, Thomas, Wordeman, Linda, Holland, Eric, Stella, Nephi
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Drug Discovery
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847318/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.280
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