CBMT-19. THE ALTERNATIVE LENGTHENING OF TELOMERE (ALT) MECHANISM PROVIDES COLLATERAL SENSITIVITY TO LETHAL TELOMERIC FUSION INDUCED BY TRAPPING PARP INHIBITORS

A subset of human tumors, including all IDH1-mutant astrocytomas, use a homologous recombination-based alternative lengthening of telomere (ALT) pathway to resolve telomeric dysfunction in the absence of TERT. Because ALT is not used by normal cells, targeting of the process may provide new therapeu...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Mukherjee, Joydeep, Dalle-Ore, Cecelia, Johanessen, Tor-Christian, Pandita, Ajay, Ohba, Shigeo, Cahill, Daniel, Pieper, Russell O
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Cell Biology and Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847291/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.141
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