DDIS-33. SELECTIVE AND COMPLETE INHIBITION OF mTORC1 BY BI-STERIC mTOR INHIBITORS DRIVES THERAPEUTIC RESPONSE IN GLIOBLASTOMA

Activation of phosphatidylinositol 3-kinase (PI3K)/PTEN pathway and oncogenic signaling via the mechanistic target of rapamycin (mTOR) occur in a majority of high-grade glial brain tumors. Allosteric mTOR inhibitors, such as rapamycin and other rapalogs, incompletely block mTORC1 by reducing phospho...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Wen Fan, Qi, Lorenzana, Edward, Luo, Xujun, Lea, Robin, Aksoy, Ozlem, An, Zhenyi, Ozawa, Tomoko, Wassarman, Douglas, Shokat, Kevan, Aggen, James, Smith, Jaqueline A M, Singh, Mallika, Butowski, Nicholas, Raleigh, David, Weiss, William
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Drug Discovery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847061/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.284
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados