DDIS-33. SELECTIVE AND COMPLETE INHIBITION OF mTORC1 BY BI-STERIC mTOR INHIBITORS DRIVES THERAPEUTIC RESPONSE IN GLIOBLASTOMA

Activation of phosphatidylinositol 3-kinase (PI3K)/PTEN pathway and oncogenic signaling via the mechanistic target of rapamycin (mTOR) occur in a majority of high-grade glial brain tumors. Allosteric mTOR inhibitors, such as rapamycin and other rapalogs, incompletely block mTORC1 by reducing phospho...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Neuro Oncol
मुख्य लेखकों: Wen Fan, Qi, Lorenzana, Edward, Luo, Xujun, Lea, Robin, Aksoy, Ozlem, An, Zhenyi, Ozawa, Tomoko, Wassarman, Douglas, Shokat, Kevan, Aggen, James, Smith, Jaqueline A M, Singh, Mallika, Butowski, Nicholas, Raleigh, David, Weiss, William
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2019
विषय:
Drug Discovery
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847061/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.284
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