GENE-40. CHARACTERIZING EPIGENETIC INTRATUMORAL HETEROGENEITY IN GLIOMA USING SINGLE-CELL BISULFITE SEQUENCING

Genetic and epigenetic alterations contribute to the observed intratumoral heterogeneity in adult glioma. Current glioma classification, based on genotype (e.g., IDH1 mutations) and DNA methylation profiles (e.g., glioma CpG Island Methylator Phenotype), can provide clinically relevant tumor subgrou...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Johnson, Kevin C, Anderson, Kevin, Courtois, Elise, Barthel, Floris, Samuels, Michael, Robson, Paul, Bulsara, Ketan, Das, Sunit, Verhaak, Roel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Genetics and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846935/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.442
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