PATH-45. INTEGRATION OF MULTI-REGION (EPI)GENOMICS WITH MULTIMODALITY ADVANCED IMAGING HIGHLIGHTS GLIOMA INTRATUMORAL HETEROGENEITY

INTRODUCTION: Intratumoral (epi)genetic heterogeneity is recognized to be an important driver in glioma therapy resistance. A single biopsy is unlikely to represent the true spatial and temporal heterogeneity. Therefore, multiple sampling schemes guided by imaging are needed. METHODS: We obtained 74...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Verburg, Niels, Johnson, Kevin C, Barthel, Floris P, Taylor, Michael, Costello, Joseph, Hamer, Philip C de Witt, Wesseling, Pieter, Verhaak, Roel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692368/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.735
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